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Týdningur av angiotensin converting enzyme virkisstigi fyri tillaging til kropsliga venjing.


Tórur Sjúrðarson

Deildini fyri Heilsu og Sjúkrarøkt, Fróðskaparsetrið

Aðrir luttakarar:
Nikolai Baastrup Nordsborg, Associate professor, PhD in exercise

Februar 2019 - 31.07.2022

Samlaður kostnaður:
kr. 2.194.297

Stuðul úr Granskingargrunninum:
kr. 1.100.000

The present ͞ACE follow-up͟ project lasts two years and will result in a ph.d. within ‘personalized exercise prescription͛ originating from the University of Faroe Islands and University of Copenhagen. The first year of the project has been completed in 2019, where 51 participants successfully completed an 8-week exercise training intervention in Torshavn. Scientific background Cardiorespiratory fitness or maximal oxygen uptake (VO2max) is a robust index of all-cause mortality. Human VO2max differs more than four fold in an age and gender-specific comparison and is generally improved by exercise training. However, exercise training causes a highly individual increase of VO2max ranging from 0-50%. It is of obvious importance to determine the underlying mechanisms for the individual response to exercise training, since these directly influence health. Additionally, a deep phenotypic investigation is required, because VO2max is only a crude measure of cardio-respiratory capacity. A potential decisive factor for the individual exercise training adaptation in humans is the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene. Thus, the present study utilizes a high number of obtained physiological measurements and samples from an exercise-training study including carriers of ACE II, ID and DD genotypes who were randomly allocated to treatment with the ACE inhibitor Enalapril ® in order to manipulate the resulting phenotype. Project content The primary tasks of the remaining 2 year ph.d. project is completion of the deep phenotype analyses. This will consist of muscle tissue analysis at the University of Copenhagen (7 months) as well as analyses of obtained echocardiography recordings (6 months) and cardiac magnetic resonance imaging (5 months) on the National hospital of the Faroe Islands. Subsequently, the ph.d. candidate will be responsible for the publication process (3 months) and completing a thesis based on the large and demanding project (3 months). Project outcome The project will have several important outcomes: It will establish to which degree an individual variation exists in a high number of physiological variables in response to physical exercise. It will establish if the ACE genotype can predict the degree of adaptation to exercise and whether manipulation of the ACE phenotype impacts the exercise training response. All of these findings will greatly improve our understanding of personalized exercise prescription for health.

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